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Article

Snf1 Phosphorylates Adenylate Cyclase and Negatively Regulates Protein Kinase A-dependent Transcription in Saccharomyces cerevisiae.

The Journal of biological chemistry - 9 Oct 2015

Nicastro Raffaele, Tripodi Farida, Gaggini Marco, Castoldi Andrea, Reghellin Veronica, Nonnis Simona, Tedeschi Gabriella, Coccetti Paola

Abstract excerpt

In eukaryotes, nutrient availability and metabolism are coordinated by sensing mechanisms and signaling pathways, which influence a broad set of cellular functions such as transcription and metabolic pathways to match environmental conditions. In yeast, PKA is activated in the presence of high glucose concentrations, favoring fast nutrient utilization, shutting down stress responses, and boosting growth. On the...

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Identifiers

PMID: 26309257
DOI: 10.1074/jbc.M115.658005
PMCID: PMC4598984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Snf1 Phosphorylates Adenylate Cyclase and Negatively Regulates Protein Kinase A-dependent Transcription in Saccharomyces cerevisiae.PMID 26309257Read ↗

Protein kinase A contributes to the negative control of Snf1 protein kinase in Saccharomyces cerevisiae.Semantic proximity Read ↗

Glucose regulates transcription in yeast through a network of signaling pathways.Semantic proximity Read ↗

Snf1 controls the activity of adr1 through dephosphorylation of Ser230.Semantic proximity Read ↗

ADP regulates SNF1, the Saccharomyces cerevisiae homolog of AMP-activated protein kinase.Semantic proximity Read ↗

Target of Rapamycin (TOR) in Nutrient Signaling and Growth ControlSemantic proximity Read ↗

Deletion of SNF1 affects the nutrient response of yeast and resembles mutations which activate the adenylate cyclase pathway.Semantic proximity Read ↗

Two glucose-sensing pathways converge on Rgt1 to regulate expression of glucose transporter genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

Sensing nutrient and energy status by SnRK1 and TOR kinases.Semantic proximity Read ↗

Protein kinase Snf1 is involved in the proper regulation of the unfolded protein response in Saccharomyces cerevisiae.Semantic proximity Read ↗

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A mutation in Saccharomyces cerevisiae adenylate cyclase, Cyr1K1876M, specifically affects glucose- and acidification-induced cAMP signalling and not the basal cAMP level.Semantic proximity Read ↗

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