Article
Notch signaling deregulation in multiple myeloma: A rational molecular target.
Oncotarget - 29 Sept 2015
Colombo Michela, Galletti Serena, Garavelli Silvia, Platonova Natalia, Paoli Alessandro, Basile Andrea, Taiana Elisa, Neri Antonino, Chiaramonte Raffaella
Abstract excerpt
Despite recent therapeutic advances, multiple myeloma (MM) is still an incurable neoplasia due to intrinsic or acquired resistance to therapy. Myeloma cell localization in the bone marrow milieu allows direct interactions between tumor cells and non-tumor bone marrow cells which promote neoplastic cell growth, survival, bone disease, acquisition of drug resistance and consequent relapse. Twenty percent of MM...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.