Article
Clinical impact on ovarian cancer patients of massive parallel sequencing for BRCA mutation detection: the experience at Gemelli hospital and a literature review.
Expert review of molecular diagnostics - 1 Jan 2015
Minucci Angelo, Scambia Giovanni, Santonocito Concetta, Concolino Paola, Canu Giulia, Mignone Flavio, Saggese Igor, Guarino Donatella, Costella Alessandra, Molinario Rossana, De Bonis Maria, Ferrandina Gabriella, Petrillo Marco, Scaglione Giovanni Luca, Capoluongo Ettore
Abstract excerpt
OBJECTIVE: Massive parallel sequencing (MPS) is the new frontier for molecular diagnostics. Twenty-four papers regarding BRCA analysis were considered for reviewing all pipelines evaluated in this field. METHODS: Proposed here is an integrated MPS workflow able to successfully identify BRCA1/2 mutational status on 212 Italian ovarian cancer patients. The review of literature data is reported. RESULT: The pipeline...
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