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Article

Simultaneous detection of BRCA mutations and large genomic rearrangements in germline DNA and FFPE tumor samples.

Oncotarget - 20 Sept 2016

Enyedi Márton Zsolt, Jaksa Gábor, Pintér Lajos, Sükösd Farkas, Gyuris Zoltán, Hajdu Adrienn, Határvölgyi Erika, Priskin Katalin, Haracska Lajos

Abstract excerpt

The development of breast and ovarian cancer is strongly connected to the inactivation of the BRCA1 and BRCA2 genes by different germline and somatic alterations, and their diagnosis has great significance in targeted tumor therapy, since recently approved PARP inhibitors show high efficiency in the treatment of BRCA-deficient tumors. This raises the need for new diagnostic methods that are capable of performing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27533253
DOI: 10.18632/oncotarget.11259
PMCID: PMC5308695

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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