Article
Activation of Mir-29a in Activated Hepatic Stellate Cells Modulates Its Profibrogenic Phenotype through Inhibition of Histone Deacetylases 4.
PloS one - 1 Jan 2015
Huang Ying-Hsien, Tiao Mao-Meng, Huang Li-Tung, Chuang Jiin-Haur, Kuo Kuang-Che, Yang Ya-Ling, Wang Feng-Sheng
Abstract excerpt
BACKGROUND: Recent studies have shown that microRNA-29 (miR-29) is significantly decreased in liver fibrosis and that its downregulation influences the activation of hepatic stellate cells (HSCs). In addition, inhibition of the activity of histone deacetylases 4 (HDAC4) has been shown to strongly reduce HSC activation in the context of liver fibrosis. OBJECTIVES: In this study, we examined whether miR-29a was...
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