Article
Citalopram for the Treatment of Agitation in Alzheimer Dementia: Genetic Influences.
Journal of geriatric psychiatry and neurology - 1 Mar 2016
Peters Matthew E, Vaidya Vijay, Drye Lea T, Devanand Davangere P, Mintzer Jacobo E, Pollock Bruce G, Porsteinsson Anton P, Rosenberg Paul B, Schneider Lon S, Shade David M, Weintraub Daniel, Yesavage Jerome, Lyketsos Constantine G, Avramopoulos Dimitri
Abstract excerpt
OBJECTIVE: To assess potential genetic influences on citalopram treatment efficacy for agitation in individuals with Alzheimer dementia (AD). Six functional genetic variants were studied in the following genes: serotonin receptor 2A (HTR2A-T102C), serotonin receptor 2C (HTR2C-Cys23Ser), serotonin transporter (5HTT-LPR), brain-derived neurotropic factor (BDNF-Val66Met), apolipoprotein E (ε2, ε3, ε4 variants), and...
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