Article
Role of 5HT 2A and 5HT 2C polymorphisms in behavioural and psychological symptoms of Alzheimer's disease.
Neurobiology of aging - 1 Mar 2008
Pritchard Antonia L, Harris Judith, Pritchard Colin W, Coates John, Haque Sayeed, Holder Roger, Bentham Peter, Lendon Corinne L
Abstract excerpt
OBJECTIVE: Alzheimer's disease (AD) patients suffer from behavioural and psychological symptoms of dementia (BPSD). A genetic component to BPSD development in AD has been demonstrated. Polymorphisms within serotonin receptors 5HT(2A) and 5HT(2C) have been previously investigated in a few interesting studies reviewed here, however, their role remains unclear. METHODS: Our large cohort of 394 patients had...
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