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Article

Sertraline for the treatment of depression in Alzheimer disease: genetic influences.

Journal of geriatric psychiatry and neurology - 1 Dec 2011

Peters Matthew E, Vaidya Vijay, Drye Lea T, Rosenberg Paul B, Martin Barbara K, Porsteinsson Anton P, Frangakis Constantine E, Mintzer Jacobo, Weintraub Daniel, Schneider Lon S, Rabins Peter V, Munro Cynthia A, Meinert Curtis L, Lyketsos Constantine G, Avramopoulos Dimitri, Dimitri Avramopoulos

Abstract excerpt

OBJECTIVE: To assess the potential for genetic influences on sertraline treatment efficacy for depression of Alzheimer disease (dAD). Four functional genetic variants were studied: 2 serotonin receptors (HTR2A-T102C and HTR2C-Cys23Ser), the serotonin transporter (5HTT-LPR), and brain-derived neurotrophic factor (BDNF-Val66Met). Treatment response by genotype was measured by (1) the modified Alzheimer's Disease...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

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Source

Open in PubMed Open full text

Identifiers

PMID: 22228829
DOI: 10.1177/0891988711422527
PMCID: PMC3535452

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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