Article
Hsa-mir-27a genetic variant contributes to gastric cancer susceptibility through affecting miR-27a and target gene expression.
Cancer science - 1 Oct 2010
Sun Qingmin, Gu Haijuan, Zeng Ying, Xia Yi, Wang You, Jing Yali, Yang Li, Wang Bin
Abstract excerpt
Aberrant microRNA (miRNA) expression is presently proposed to correlate with various human cancers and common single-nucleotide polymorphisms (SNP) at miRNA genes can influence the maturation of miRNAs or miRNA-mediated transcriptional regulation. However, whether miRNAs SNP alter gastric cancer susceptibility is still unclear. Here we investigated the possible role of a common A/G polymorphism (rs895819) within...
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