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Article

Transforming Growth Factor β–SMAD2 Signaling Regulates Aortic Arch Innervation and Development

5 Nov 2004

Abstract excerpt

Aortic arch interruptions in humans and animal models are mainly caused by aberrant development of the fourth pharyngeal arch artery. Little is known about the maturation of this vessel during normal and abnormal development, which is the subject of this study. Tgfbeta2 knockout mice that present with fourth artery defects have been associated with defective neural crest cell migration. In this study, we...

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Share to Aortic Disease and Treatment Approaches
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PMID: 15528466
DOI: 10.1161/01.res.0000150047.16909.ab

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