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Article

Mutations in the BCR-ABL1 Kinase Domain and Elsewhere in Chronic Myeloid Leukemia.

Clinical lymphoma, myeloma & leukemia - 1 Jun 2015

Soverini Simona, de Benedittis Caterina, Mancini Manuela, Martinelli Giovanni

Abstract excerpt

Chronic myeloid leukemia (CML) has been the first human malignancy to be associated, more than 50 years ago, with a consistent chromosomal abnormality--the t(9;22)(q34;q11) chromosomal translocation. The resulting BCR-ABL1 fusion gene, encoding a tyrosine kinase with deregulated activity, has a central role in the pathogenesis of CML. Ancestral or additional genetic events necessary for CML to develop have long...

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Topics

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Share to Antineoplastic Agents
Share to Fusion Proteins, bcr-abl

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to IKZF1 gene

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

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Share to Nucleophosmin

Share to Protein Kinase Inhibitors

Share to Protein Structure, Tertiary

Source

Identifiers

PMID: 26297264
DOI: 10.1016/j.clml.2015.02.035

Genes

ABL1
BCR
ASXL1
RUNX1
TET2
CBL
IDH1
IDH2
IKZF1
KRAS
NPM1
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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