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Rickettsia typhi Possesses Phospholipase A2 Enzymes that Are Involved in Infection of Host Cells

20 Jun 2013

Abstract excerpt

The long-standing proposal that phospholipase A2 (PLA2) enzymes are involved in rickettsial infection of host cells has been given support by the recent characterization of a patatin phospholipase (Pat2) with PLA2 activity from the pathogens Rickettsia prowazekii and R. typhi. However, pat2 is not encoded in all Rickettsia genomes; yet another uncharacterized patatin (Pat1) is indeed ubiquitous. Here,...

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PMID: 23818842
DOI: 10.1371/journal.ppat.1003399

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