Monocyte Phenotype and Polyfunctionality Are Associated With Elevated Soluble Inflammatory Markers, Cytomegalovirus Infection, and Functional and Cognitive Decline in Elderly Adults.

doi:10.1093/gerona/glv121

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Article

Monocyte Phenotype and Polyfunctionality Are Associated With Elevated Soluble Inflammatory Markers, Cytomegalovirus Infection, and Functional and Cognitive Decline in Elderly Adults.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 May 2016

de Pablo-Bernal Rebeca Sara, Cañizares Julio, Rosado Isaac, Galvá María Isabel, Alvarez-Ríos Ana Isabel, Carrillo-Vico Antonio, Ferrando-Martínez Sara, Muñoz-Fernández María Ángeles, Rafii-El-Idrissi Benhnia Mohammed, Pacheco Yolanda María, Ramos Raquel, Leal Manuel, Ruiz-Mateos Ezequiel

Abstract excerpt

Monocytes are mediators of the inflammatory response and include three subsets: classical, intermediate, and nonclassical. Little is known about the phenotypical and functional age-related changes in monocytes and their association with soluble inflammatory biomarkers, cytomegalovirus infection, and functional and mental decline. We assayed the activation ex vivo and the responsiveness to TLR2 and TLR4 agonists...

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PMID: 26286603
DOI: 10.1093/gerona/glv121
PMCID: PMC5007736

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TLR2
TLR4
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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