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Article

Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function.

Aging cell - 1 Oct 2012

Hearps Anna C, Martin Genevieve E, Angelovich Thomas A, Cheng Wan-Jung, Maisa Anna, Landay Alan L, Jaworowski Anthony, Crowe Suzanne M

Abstract excerpt

Chronic inflammation in older individuals is thought to contribute to inflammatory, age-related diseases. Human monocytes are comprised of three subsets (classical, intermediate and nonclassical subsets), and despite being critical regulators of inflammation, the effect of age on the functionality of monocyte subsets remains to be fully defined. In a cross-sectional study involving 91 healthy male (aged 20-84...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22708967
DOI: 10.1111/j.1474-9726.2012.00851.x

Genes

CXCL10
TLR4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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