Article
Systematic chromatin state comparison of epigenomes associated with diverse properties including sex and tissue type.
Nature communications - 18 Aug 2015
Yen Angela, Kellis Manolis
Abstract excerpt
Epigenomic data sets provide critical information about the dynamic role of chromatin states in gene regulation, but a key question of how chromatin state segmentations vary under different conditions across the genome has remained unaddressed. Here we present ChromDiff, a group-wise chromatin state comparison method that generates an information-theoretic representation of epigenomes and corrects for external...
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