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Article

Lumbar Disc Degeneration is Facilitated by MiR-100-Mediated FGFR3 Suppression

1 Jan 2015

Abstract excerpt

BACKGROUND/AIMS: The pathogenesis of lumbar disc degeneration (LDD) involved activation of matrix metalloproteinase 13 (MMP13) by differential expression of fibroblast growth factor receptor 1 (FGFR1) and FGFR3. Nevertheless, the molecular regulation of FGFR1 and FGFR3 in the lumber disc cells remains elusive. METHODS: We examined the FGFR1 and FGFR3 levels and microRNAs (miRNAs) levels in the resected LDD discs,...

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PMID: 26279428
DOI: 10.1159/000430187

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