Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Downregulation of miR-27b is Involved in Loss of Type II Collagen by Directly Targeting Matrix Metalloproteinase 13 (MMP13) in Human Intervertebral Disc Degeneration

18 Nov 2015

Abstract excerpt

STUDY DESIGN: A microRNA (miRNA) study. OBJECTIVE: The purpose of this study was to identify intervertebral disc degeneration (IDD)-specific miRNAs, followed by functional validation of results. SUMMARY OF BACKGROUND DATA: IDD is the major contributor to back radicular pain, and the molecular mechanisms underlying this disease are not completely understood. Accumulating evidence suggests that miRNAs play an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cervical and Thoracic Myelopathy
Share to Spine and Intervertebral Disc Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26583473
DOI: 10.1097/brs.0000000000001139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Downregulation of miR-27b is Involved in Loss of Type II Collagen by Directly Targeting Matrix Metalloproteinase 13 (MMP13) in Human Intervertebral Disc DegenerationPMID 26583473Read ↗

Dysregulated miR-133a Mediates Loss of Type II Collagen by Directly Targeting Matrix Metalloproteinase 9 (MMP9) in Human Intervertebral Disc DegenerationSemantic proximity Read ↗

MicroRNA-93 regulates collagen loss by targeting MMP3 in human nucleus pulposus cells.Semantic proximity Read ↗

Role of microRNAs in intervertebral disc degeneration (Review)Semantic proximity Read ↗

The Mechanism and Function of <scp>miRNA</scp> in Intervertebral Disc DegenerationSemantic proximity Read ↗

Dysregulated miR-98 Contributes to Extracellular Matrix Degradation by Targeting IL-6/STAT3 Signaling Pathway in Human Intervertebral Disc DegenerationSemantic proximity Read ↗

The role of miRNA, lncRNA and circRNA in the development of intervertebral disk degeneration (Review)Semantic proximity Read ↗

A Bioinformatic Analysis of MicroRNAs’ Role in Human Intervertebral Disc DegenerationSemantic proximity Read ↗

MicroRNA-338-3p as a novel therapeutic target for intervertebral disc degeneration.Semantic proximity Read ↗

Screening of miR-15a-5p as a potential biomarker for intervertebral disc degeneration through RNA-sequencingSemantic proximity Read ↗

Long non-coding RNA PART1 promotes intervertebral disc degeneration through regulating the�miR‑93/MMP2 pathway in nucleus pulposus cellsSemantic proximity Read ↗

Characterization of microRNA expression profiles in patients with intervertebral disc degenerationSemantic proximity Read ↗

Role of the miR-133a-5p/FBXO6 axis in the regulation of intervertebral disc degenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.