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Dysregulated miR-133a Mediates Loss of Type II Collagen by Directly Targeting Matrix Metalloproteinase 9 (MMP9) in Human Intervertebral Disc Degeneration

11 Dec 2015

Abstract excerpt

STUDY DESIGN: A microRNA (miRNA) study using Solexa sequencing. OBJECTIVE: The purpose of this study was to identify intervertebral disc degeneration (IDD)-specific miRNA expression profile, and to validate its biological function. SUMMARY OF BACKGROUND DATA: Accumulating evidence indicates that miRNAs play a critical role in IDD, but the role of specific miRNAs involved in this entity remains unclear. METHODS:...

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PMID: 26656045
DOI: 10.1097/brs.0000000000001375

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