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Article

Targeted inhibition of metastatic melanoma through interference with Pin1-FOXM1 signaling.

Oncogene - 28 Apr 2016

Kruiswijk F, Hasenfuss S C, Sivapatham R, Baar M P, Putavet D, Naipal K A T, van den Broek N J F, Kruit W, van der Spek P J, van Gent D C, Brenkman A B, Campisi J, Burgering B M T, Hoeijmakers J H J, de Keizer P L J

Abstract excerpt

Melanoma is the most lethal form of skin cancer and successful treatment of metastatic melanoma remains challenging. BRAF/MEK inhibitors only show a temporary benefit due to rapid occurrence of resistance, whereas immunotherapy is mainly effective in selected subsets of patients. Thus, there is a need to identify new targets to improve treatment of metastatic melanoma. To this extent, we searched for markers that...

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Source

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Identifiers

PMID: 26279295
DOI: 10.1038/onc.2015.282
PMCID: PMC4757516

Genes

FOXM1
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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