Reversal of the glycolytic phenotype of primary effusion lymphoma cells by combined targeting of cellular metabolism and PI3K/Akt/ mTOR signaling.

doi:10.18632/oncotarget.6315

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Article

Reversal of the glycolytic phenotype of primary effusion lymphoma cells by combined targeting of cellular metabolism and PI3K/Akt/ mTOR signaling.

Oncotarget - 2 Feb 2016

Mediani Laura, Gibellini Federica, Bertacchini Jessika, Frasson Chiara, Bosco Raffaella, Accordi Benedetta, Basso Giuseppe, Bonora Massimo, Calabrò Maria Luisa, Mattiolo Adriana, Sgarbi Gianluca, Baracca Alessandra, Pinton Paolo, Riva Giovanni, Rampazzo Enrico, Petrizza Luca, Prodi Luca, Milani Daniela, Luppi Mario, Potenza Leonardo, De Pol Anto, Cocco Lucio, Capitani Silvano, Marmiroli Sandra

Abstract excerpt

PEL is a B-cell non-Hodgkin lymphoma, occurring predominantly as a lymphomatous effusion in body cavities, characterized by aggressive clinical course, with no standard therapy. Based on previous reports that PEL cells display a Warburg phenotype, we hypothesized that the highly hypoxic environment in which they grow in vivo makes them more reliant on glycolysis, and more vulnerable to drugs targeting this...

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PMID: 26575168
DOI: 10.18632/oncotarget.6315
PMCID: PMC4868703

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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