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Article

Variants in the Regulatory Region of WNT5A Reduced Risk of Cardiac Conotruncal Malformations in the Chinese Population.

Scientific reports - 17 Aug 2015

Li Peiqiang, Li Haijie, Zheng Yufang, Qiao Bin, Duan Wenyuan, Huang Lijuan, Liu Weiqi, Wang Hongyan

Abstract excerpt

WNT5A is one of the most highly investigated non-canonical Wnt ligands and is involved in the embryonic heart development, especially in formation of the cardiac conotruncal region by regulating the migration and differentiation of cardiac neural crest (CNC) and second heart field (SHF) cells. No study to date has comprehensively characterized the WNT5A regulatory variants in patients with congenital heart...

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Source

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Identifiers

PMID: 26278011
DOI: 10.1038/srep13120
PMCID: PMC4538571

Genes

SHF
SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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