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Article

Seipin is involved in the regulation of phosphatidic acid metabolism at a subdomain of the nuclear envelope in yeast.

Biochimica et biophysica acta - 1 Nov 2015

Wolinski Heimo, Hofbauer Harald F, Hellauer Klara, Cristobal-Sarramian Alvaro, Kolb Dagmar, Radulovic Maja, Knittelfelder Oskar L, Rechberger Gerald N, Kohlwein Sepp D

Abstract excerpt

Yeast Fld1 and Ldb16 resemble mammalian seipin, implicated in neutral lipid storage. Both proteins form a complex at the endoplasmic reticulum-lipid droplet (LD) interface. Malfunction of this complex either leads to LD clustering or to the generation of supersized LD (SLD) in close vicinity to the nuclear envelope, in response to altered phospholipid (PL) composition. We show that similar to mutants lacking...

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Identifiers

PMID: 26275961
DOI: 10.1016/j.bbalip.2015.08.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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