Article
Molecular Basis of Gene-Gene Interaction: Cyclic Cross-Regulation of Gene Expression and Post-GWAS Gene-Gene Interaction Involved in Atrial Fibrillation.
PLoS genetics - 1 Aug 2015
Huang Yufeng, Wang Chuchu, Yao Yufeng, Zuo Xiaoyu, Chen Shanshan, Xu Chengqi, Zhang Hongfu, Lu Qiulun, Chang Le, Wang Fan, Wang Pengxia, Zhang Rongfeng, Hu Zhenkun, Song Qixue, Yang Xiaowei, Li Cong, Li Sisi, Zhao Yuanyuan, Yang Qin, Yin Dan, Wang Xiaojing, Si Wenxia, Li Xiuchun, Xiong Xin, Wang Dan, Huang Yuan, Luo Chunyan, Li Jia, Wang Jingjing, Chen Jing, Wang Longfei, Wang Li, Han Meng, Ye Jian, Chen Feifei, Liu Jingqiu, Liu Ying, Wu Gang, Yang Bo, Cheng Xiang, Liao Yuhua, Wu Yanxia, Ke Tie, Chen Qiuyun, Tu Xin, Elston Robert, Rao Shaoqi, Yang Yanzong, Xia Yunlong, Wang Qing K
Abstract excerpt
Atrial fibrillation (AF) is the most common cardiac arrhythmia at the clinic. Recent GWAS identified several variants associated with AF, but they account for <10% of heritability. Gene-gene interaction is assumed to account for a significant portion of missing heritability. Among GWAS loci for AF, only three were replicated in the Chinese Han population, including SNP rs2106261 (G/A substitution) in ZFHX3,...
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