Article
Adaptive mutations in sugar metabolism restore growth on glucose in a pyruvate decarboxylase negative yeast strain.
Microbial cell factories - 8 Aug 2015
Zhang Yiming, Liu Guodong, Engqvist Martin K M, Krivoruchko Anastasia, Hallström Björn M, Chen Yun, Siewers Verena, Nielsen Jens
Abstract excerpt
BACKGROUND: A Saccharomyces cerevisiae strain carrying deletions in all three pyruvate decarboxylase (PDC) genes (also called Pdc negative yeast) represents a non-ethanol producing platform strain for the production of pyruvate derived biochemicals. However, it cannot grow on glucose as the sole carbon source, and requires supplementation of C2 compounds to the medium in order to meet the requirement for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.