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Crystal Structure of a Histone Deacetylase Homologue from Pseudomonas aeruginosa

14 Nov 2016

Abstract excerpt

Despite the recently growing interest in the acetylation of lysine residues by prokaryotic enzymes, the underlying biological function is still not well understood. Deacetylation is accomplished by proteins that belong to the histone deacetylase (HDAC) superfamily. In this report, we present the first crystal structure of PA3774, a histone deacetylase homologue from the human pathogen Pseudomonas aeruginosa that...

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PMID: 27951649
DOI: 10.1021/acs.biochem.6b00613

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