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Article

Label-free optical detection of single-base mismatches by the combination of nuclease and gold nanoparticles.

Biosensors & bioelectronics - 15 Jul 2011

Liu Meiying, Yuan Min, Lou Xinhui, Mao Hongju, Zheng Dongmei, Zou Ruxing, Zou Nengli, Tang Xiangrong, Zhao Jianlong

Abstract excerpt

We report here an optical approach that enables highly selective and colorimetric single-base mismatch detection without the need of target modification, precise temperature control or stringent washes. The method is based on the finding that nucleoside monophosphates (dNMPs), which are digested elements of DNA, can better stabilize unmodified gold nanoparticles (AuNPs) than single-stranded DNA (ssDNA) and...

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Identifiers

PMID: 21605966
DOI: 10.1016/j.bios.2011.04.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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