Article
Characterization of AmpC β-lactamase mutations of extensively drug-resistant Pseudomonas aeruginosa isolates that develop resistance to ceftolozane/tazobactam during therapy.
Enfermedades infecciosas y microbiologia clinica (English ed.) - 1 Dec 2020
Fernández-Esgueva Marta, López-Calleja Ana Isabel, Mulet Xavier, Fraile-Ribot Pablo A, Cabot Gabriel, Huarte Rafael, Rezusta Antonio, Oliver Antonio
Abstract excerpt
INTRODUCTION: We characterized AmpC β-lactamase mutations that resulted in ceftolozane/tazobactam resistance in extensively drug-resistant (XDR) Pseudomonas aeruginosa isolates recovered from patients treated with this agent from June 2016 to December 2018. METHODS: Five pairs of ceftolozane/tazobactam susceptible/resistant P. aeruginosa XDR isolates were included among a total of 49 patients treated. Clonal...
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