Article
Pre-existing minor variants with NS5A L31M/V-Y93H double substitution are closely linked to virologic failure with asunaprevir plus daclatasvir treatment for genotype 1b hepatitis C virus infection.
PloS one - 1 Jan 2020
Morishita Naoki, Sakamori Ryotaro, Yamada Tomomi, Kai Yugo, Tahata Yuki, Urabe Ayako, Yamada Ryoko, Kodama Takahiro, Hikita Hayato, Doi Yoshinori, Tamura Shinji, Hagiwara Hideki, Imai Yasuharu, Iio Sadaharu, Tatsumi Tomohide, Takehara Tetsuo
Abstract excerpt
BACKGROUND: L31 and Y93 in the NS5A region of the hepatitis C virus (HCV) are the most important substitution positions associated with resistance to direct-acting antiviral (DAA) treatment. METHODS: We analyzed the frequency of NS5A L31M/V and Y93/H in NS5A inhibitor-naive HCV genotype 1 patients who received asunaprevir plus daclatasvir combination treatment using a conventional sequencing method and a deep...
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