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Article

An Extended, Boolean Model of the Septation Initiation Network in S.Pombe Provides Insights into Its Regulation.

PloS one - 1 Jan 2015

Chasapi Anastasia, Wachowicz Paulina, Niknejad Anne, Collin Philippe, Krapp Andrea, Cano Elena, Simanis Viesturs, Xenarios Ioannis

Abstract excerpt

Cytokinesis in fission yeast is controlled by the Septation Initiation Network (SIN), a protein kinase signaling network using the spindle pole body as scaffold. In order to describe the qualitative behavior of the system and predict unknown mutant behaviors we decided to adopt a Boolean modeling approach. In this paper, we report the construction of an extended, Boolean model of the SIN, comprising most SIN...

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Identifiers

PMID: 26244885
DOI: 10.1371/journal.pone.0134214
PMCID: PMC4526654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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An Extended, Boolean Model of the Septation Initiation Network in S.Pombe Provides Insights into Its Regulation.PMID 26244885Read ↗

Modeling the septation initiation network (SIN) in fission yeast cells.Semantic proximity Read ↗

Identification of functional domains within the septation initiation network kinase, Cdc7.Semantic proximity Read ↗

The Schizosaccharomyces pombe septation initiation network (SIN) is required for spore formation in meiosis.Semantic proximity Read ↗

Chemical genetic analysis of the regulatory role of Cdc2p in the S. pombe septation initiation network.Semantic proximity Read ↗

Analysis of the S. pombe signalling scaffold protein Cdc11p reveals an essential role for the N-terminal domain in SIN signalling.Semantic proximity Read ↗

Mitotic hyperphosphorylation of the fission yeast SIN scaffold protein cdc11p is regulated by the protein kinase cdc7p.Semantic proximity Read ↗

S. pombe cdc11p, together with sid4p, provides an anchor for septation initiation network proteins on the spindle pole body.Semantic proximity Read ↗

The nuclear kinase Lsk1p positively regulates the septation initiation network and promotes the successful completion of cytokinesis in response to perturbation of the actomyosin ring in Schizosaccharomyces pombe.Semantic proximity Read ↗

The role of Plo1 kinase in mitotic commitment and septation in Schizosaccharomyces pombe.Semantic proximity Read ↗

Correct regulation of the septation initiation network in Schizosaccharomyces pombe requires the activities of par1 and par2.Semantic proximity Read ↗

Timely septation requires SNAD-dependent spindle pole body localization of the septation initiation network components in the filamentous fungus Aspergillus nidulans.Semantic proximity Read ↗

Etd1p is a novel protein that links the SIN cascade with cytokinesis.Semantic proximity Read ↗

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