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Article

Chemical genetic analysis of the regulatory role of Cdc2p in the S. pombe septation initiation network.

Journal of cell science - 15 Mar 2008

Dischinger Sandra, Krapp Andrea, Xie Linfeng, Paulson James R, Simanis Viesturs

Abstract excerpt

The protein kinase Cdc2p is the master regulator of cell cycle progression in the fission yeast Schizosaccharomyces pombe. It is required both for entry into mitosis and for onset of DNA replication. Cdc2p must be inactivated to permit exit from mitosis, licensing of replication origins and cytokinesis. To study the role of Cdc2p in greater detail, we generated a cdc2 allele that is sensitive to an inhibitory ATP...

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Identifiers

PMID: 18303049
DOI: 10.1242/jcs.021584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Chemical genetic analysis of the regulatory role of Cdc2p in the S. pombe septation initiation network.PMID 18303049Read ↗

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The Schizosaccharomyces pombe cdc14 gene is required for septum formation and can also inhibit nuclear division.Semantic proximity Read ↗

A checkpoint that monitors cytokinesis in Schizosaccharomyces pombe.Semantic proximity Read ↗

The Schizosaccharomyces pombe septation initiation network (SIN) is required for spore formation in meiosis.Semantic proximity Read ↗

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Independent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stability.Semantic proximity Read ↗

Characterization of ypa1 and ypa2, the Schizosaccharomyces pombe orthologs of the peptidyl proyl isomerases that activate PP2A, reveals a role for Ypa2p in the regulation of cytokinesis.Semantic proximity Read ↗

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