Article
Clinical value of ultradeep HIV-1 genotyping and tropism testing in late presenters with advanced disease.
AIDS (London, England) - 31 Jul 2015
Casadellà Maria, Manzardo Christian, Noguera-Julian Marc, Ferrer Elena, Domingo Pere, Pérez-Álvarez Susana, Podzamczer Daniel, Plana Montserrat, Clotet Bonaventura, Gatell José M, Miró José M, Paredes Roger
Abstract excerpt
OBJECTIVE: This article aims to investigate if the detection of preexisting drug-resistant minority variant (DRMV) and/or X4 HIV-1 variants could improve the efficacy of first-line combined antiretroviral therapy (ART) in late presenters. DESIGN: Post-hoc, combined analysis of two open-label, prospective, randomized clinical trials comparing first-line ART with efavirenz (EFV) vs. ritonavir-boosted protease...
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