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Article

An Ideal PPAR Response Element Bound to and Activated by PPARα.

PloS one - 1 Jan 2015

Tzeng John, Byun Jaemin, Park Ji Yeon, Yamamoto Takanobu, Schesing Kevin, Tian Bin, Sadoshima Junichi, Oka Shin-Ichi

Abstract excerpt

Peroxisome proliferator-activated receptor-α (PPARα), a nuclear receptor, plays an important role in the transcription of genes involved in fatty acid metabolism through heterodimerization with the retinoid x receptor (RXR). The consensus sequence of the PPAR response element (PPRE) is composed of two AGGTCA-like sequences directionally aligned with a single nucleotide spacer. PPARα and RXR bind to the 5' and 3'...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26241474
DOI: 10.1371/journal.pone.0134996
PMCID: PMC4524655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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