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Telomeric repeat silencing in germ cells is essential for early development inDrosophila

3 Aug 2015

Abstract excerpt

The germline-specific role of telomeres consists of chromosome end elongation and proper chromosome segregation during early developmental stages. Despite the crucial role of telomeres in germ cells, little is known about telomere biology in the germline. We analyzed telomere homeostasis in the Drosophila female germline and early embryos. A novel germline-specific function of deadenylase complex Ccr4-Not in the...

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PMID: 26240377
DOI: 10.1093/nar/gkv775

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