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Article

Src tyrosine kinase phosphorylation of nuclear receptor HNF4α correlates with isoform-specific loss of HNF4α in human colon cancer.

Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2012

Chellappa Karthikeyani, Jankova Lucy, Schnabl Jake M, Pan Songqin, Brelivet Yann, Fung Caroline L-S, Chan Charles, Dent Owen F, Clarke Stephen J, Robertson Graham R, Sladek Frances M

Abstract excerpt

Src tyrosine kinase has long been implicated in colon cancer but much remains to be learned about its substrates. The nuclear receptor hepatocyte nuclear factor 4α (HNF4α) has just recently been implicated in colon cancer but its role is poorly defined. Here we show that c-Src phosphorylates huma...

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Identifiers

PMID: 22308320
DOI: 10.1073/pnas.1106799109
PMCID: PMC3289305

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22308320-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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