Article
Comparison against 186 canid whole-genome sequences reveals survival strategies of an ancient clonally transmissible canine tumor.
Genome research - 1 Nov 2015
Decker Brennan, Davis Brian W, Rimbault Maud, Long Adrienne H, Karlins Eric, Jagannathan Vidhya, Reiman Rebecca, Parker Heidi G, Drögemüller Cord, Corneveaux Jason J, Chapman Erica S, Trent Jeffery M, Leeb Tosso, Huentelman Matthew J, Wayne Robert K, Karyadi Danielle M, Ostrander Elaine A
Abstract excerpt
Canine transmissible venereal tumor (CTVT) is a parasitic cancer clone that has propagated for thousands of years via sexual transfer of malignant cells. Little is understood about the mechanisms that converted an ancient tumor into the world's oldest known continuously propagating somatic cell lineage. We created the largest existing catalog of canine genome-wide variation and compared it against two CTVT genome...
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