Article
Transmissible [corrected] dog cancer genome reveals the origin and history of an ancient cell lineage.
Science (New York, N.Y.) - 24 Jan 2014
Murchison Elizabeth P, Wedge David C, Alexandrov Ludmil B, Fu Beiyuan, Martincorena Inigo, Ning Zemin, Tubio Jose M C, Werner Emma I, Allen Jan, De Nardi Andrigo Barboza, Donelan Edward M, Marino Gabriele, Fassati Ariberto, Campbell Peter J, Yang Fengtang, Burt Austin, Weiss Robin A, Stratton Michael R
Abstract excerpt
Canine transmissible venereal tumor (CTVT) is the oldest known somatic cell lineage. It is a transmissible cancer that propagates naturally in dogs. We sequenced the genomes of two CTVT tumors and found that CTVT has acquired 1.9 million somatic substitution mutations and bears evidence of exposure to ultraviolet light. CTVT is remarkably stable and lacks subclonal heterogeneity despite thousands of...
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