Article
Transmissible cancers, the genomes that do not melt down.
Evolution; international journal of organic evolution - 1 Jul 2024
Bramwell Georgina, DeGregori James, Thomas Frédéric, Ujvari Beata
Abstract excerpt
Evolutionary theory predicts that the accumulation of deleterious mutations in asexually reproducing organisms should lead to genomic decay. Clonally reproducing cell lines, i.e., transmissible cancers, when cells are transmitted as allografts/xenografts, break these rules and survive for centuries and millennia. The currently known 11 transmissible cancer lineages occur in dogs (canine venereal tumour disease),...
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