Article
Population-specific genotype imputations using minimac or IMPUTE2.
Nature protocols - 1 Sept 2015
van Leeuwen Elisabeth M, Kanterakis Alexandros, Deelen Patrick, Kattenberg Mathijs V, Slagboom P Eline, de Bakker Paul I W, Wijmenga Cisca, Swertz Morris A, Boomsma Dorret I, van Duijn Cornelia M, Karssen Lennart C, Hottenga Jouke Jan
Abstract excerpt
In order to meaningfully analyze common and rare genetic variants, results from genome-wide association studies (GWASs) of multiple cohorts need to be combined in a meta-analysis in order to obtain enough power. This requires all cohorts to have the same single-nucleotide polymorphisms (SNPs) in their GWASs. To this end, genotypes that have not been measured in a given cohort can be imputed on the basis of a set...
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