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Article

A Prospective Evaluation of the Association between a Single Nucleotide Polymorphism rs3775291 in Toll-Like Receptor 3 and Breast Cancer Relapse.

PloS one - 1 Jan 2015

Chen Dan-Na, Song Chuan-Gui, Yu Ke-Da, Jiang Yi-Zhou, Ye Fu-Gui, Shao Zhi-Ming

Abstract excerpt

BACKGROUND: Toll-like receptors (TLRs) regulate the balance between the innate and adaptive immune responses. Missense single nucleotide polymorphisms (SNPs) in TLRs might be functional and thus influence the risks of chronic infection and cancer development. Here, we investigated the association of two missense SNPs, rs3775291 (c.1234G>A) in the TLR3 gene and rs4833095 (c.743T>C) in the TLR1 gene, with...

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Share to Disease-Free Survival
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Share to Neoplasm Recurrence, Local
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Source

Open in PubMed Open full text

Identifiers

PMID: 26226228
DOI: 10.1371/journal.pone.0133184
PMCID: PMC4520586

Genes

TLR3
TLR1

Variants

rs3775291
rs4833095

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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