A functional genetic variant in fragile-site gene FATS modulates the risk of breast cancer in triparous women.

doi:10.1186/s12885-015-1570-9

Article

A functional genetic variant in fragile-site gene FATS modulates the risk of breast cancer in triparous women.

BMC cancer - 30 Jul 2015

Song Fangfang, Zhang Jun, Qiu Li, Zhao Yawen, Xing Pan, Lu Jiachun, Chen Kexin, Li Zheng

Abstract excerpt

BACKGROUND: The fragile-site associated tumor suppressor (FATS, formerly known as C10orf90), a regulator of p53-p21 pathway has been involved in the onset of breast cancer. Recent data support the idea that the crosstalk between FATS and p53 may be of physiological importance for reproduction during evolution. The aim of the current study was to test the hypothesis that FATS genetic polymorphism can influence the...

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A functional genetic variant in fragile-site gene FATS modulates the risk of breast cancer in triparous women.

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