Article
Germline HABP2 Mutation Causing Familial Nonmedullary Thyroid Cancer.
The New England journal of medicine - 30 Jul 2015
Gara Sudheer Kumar, Jia Li, Merino Maria J, Agarwal Sunita K, Zhang Lisa, Cam Maggie, Patel Dhaval, Kebebew Electron
Abstract excerpt
Familial nonmedullary thyroid cancer accounts for 3 to 9% of all cases of thyroid cancer, but the susceptibility genes are not known. Here, we report a germline variant of HABP2 in seven affected members of a kindred with familial nonmedullary thyroid cancer and in 4.7% of 423 patients with thyroid cancer. This variant was associated with increased HABP2 protein expression in tumor samples from affected family...
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