G534E Variant in HABP2 and Nonmedullary Thyroid Cancer

Abstract excerpt

Recently, using next-generation sequencing (NGS) and functional studies, it has been suggested that the germline c.1601G>A variant (p.G534E, rs7080536) in HABP2 is implicated in familial nonmedullary thyroid cancer (NMTC) (1).However, the role of this variant in NMTC has been questioned due to the high reported frequencies in several public databases (2-4).Most of the subsequent replication studies have failed to...

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