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Article

Robustness of Next Generation Sequencing on Older Formalin-Fixed Paraffin-Embedded Tissue

29 Jul 2015

Abstract excerpt

Next Generation Sequencing (NGS) technologies are used to detect somatic mutations in tumors and study germ line variation. Most NGS studies use DNA isolated from whole blood or fresh frozen tissue. However, formalin-fixed paraffin-embedded (FFPE) tissues are one of the most widely available clinical specimens. Their potential utility as a source of DNA for NGS would greatly enhance population-based cancer...

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PMID: 26222067
DOI: 10.1371/journal.pone.0127353

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