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Article

Activation of the BMP-BMPR pathway conferred resistance to EGFR-TKIs in lung squamous cell carcinoma patients with EGFR mutations.

Proceedings of the National Academy of Sciences of the United States of America - 11 Aug 2015

Wang Zhijie, Shen Zhirong, Li Zhenxiang, Duan Jianchun, Fu Shuai, Liu Zhentao, Bai Hua, Zhang Zemin, Zhao Jun, Wang Xiaodong, Wang Jie

Abstract excerpt

The empirical criteria for defining a clinical subtype of lung cancer are gradually transiting from histopathology to genetic variations in driver genes. Targeting these driver mutations, such as sensitizing epidermal growth factor receptor (EGFR) mutations, has dramatically improved the prognosis of advanced non-small cell lung cancer (NSCLC). However, the clinical benefit of molecularly targeted therapy on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26216950
DOI: 10.1073/pnas.1510837112
PMCID: PMC4538677

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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