Article
Potent immunotherapy against well-established thymoma using adoptively transferred transgene IL-6-engineered dendritic cell-stimulated CD8+ T-cells with prolonged survival and enhanced cytotoxicity.
The journal of gene medicine - 1 Jan 2000
Kalyanasundaram Bhanumathy Kalpana, Zhang Bei, Xie Yufeng, Xu Aizhang, Tan Xin, Xiang Jim
Abstract excerpt
BACKGROUND: Adoptive transfer of CD8(+) T-cells specific for tumor-antigens is an attractive strategy for anti-tumor therapy. In the present study, the subsets TA and TB were used to represent the population of CD8(+) T cells generated by culturing the respective cells with irradiated dendritic cells (DCs) pulsed with ovalbumin (OVA) protein and transfected with adenoviral vector constructs as described. METHODS:...
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