Early decline in functional ovarian reserve in young women with low (CGGn < 26) FMR1 gene alleles.

doi:10.1016/j.trsl.2015.06.014

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Article

Early decline in functional ovarian reserve in young women with low (CGGn < 26) FMR1 gene alleles.

Translational research : the journal of laboratory and clinical medicine - 1 Nov 2015

Gleicher Norbert, Yu Yao, Himaya Erik, Barad David H, Weghofer Andrea, Wu Yan-Guang, Albertini David F, Wang Vicki Qi, Kushnir Vitaly A

Abstract excerpt

Mouse fmr1 models, and recent cross-sectional human data, suggest that different triple CGGn ranges of the fragile X mental retardation 1 (FMR1) gene are associated with variations in ovarian aging and infertility treatment outcomes. The FMR1 mutation affecting reproductive function most negatively in humans is the so-called low mutation, characterized by CGGn < 26. We here present a first longitudinal study of...

Topics

Adult
Alleles
Female
Fragile X Mental Retardation Protein
Humans
Ovarian Reserve
Young Adult

Source

Open in PubMed

Identifiers

PMID: 26209748
DOI: 10.1016/j.trsl.2015.06.014

Genes

FMR1
AMH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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