Article
Low and High-Normal FMR1 Triplet Cytosine, Guanine Guanine Repeats Affect Ovarian Reserve and Fertility in Women Who Underwent In Vitro Fertilization Treatment? Results from a Cross-Sectional Study.
DNA and cell biology - 1 Aug 2024
Nunes Ana Carolina Vasconcelos, Trevisan Camila Martins, Peluso Carla, Loureiro Flavia Althman, Dias Alexandre Torchio, Rincon Daniel, Fonseca Fernando Luiz Affonso, Christofolini Denise Maria, Laganà Antonio Simone, Montagna Erik, Barbosa Caio Parente, Bianco Bianca
Abstract excerpt
Dynamic mutations in the 5' untranslated region of FMR1 are associated with infertility. Premutation alleles interfere with prenatal development and increase infertility risks. The number of CGG repeats that causes the highest decrease in ovarian reserves remains unclear. We evaluated the effect of FMR1 CGG repeat lengths on ovarian reserves and in vitro fertilization (IVF) treatment outcomes in 272 women with...
Topics
- Humans
- Fragile X Mental Retardation Protein
- Female
- Fertilization in Vitro
- Ovarian Reserve
- Adult
- Cross-Sectional Studies
- Anti-Mullerian Hormone