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Article

Low urinary indoxyl sulfate levels early after transplantation reflect a disrupted microbiome and are associated with poor outcome.

Blood - 1 Oct 2015

Weber Daniela, Oefner Peter J, Hiergeist Andreas, Koestler Josef, Gessner André, Weber Markus, Hahn Joachim, Wolff Daniel, Stämmler Frank, Spang Rainer, Herr Wolfgang, Dettmer Katja, Holler Ernst

Abstract excerpt

Indole, which is produced from l-tryptophan by commensal bacteria expressing tryptophanase, not only is an important intercellular signal in microbial communities, but also modulates mucosal barrier function and expression of pro- and anti-inflammatory genes by intestinal epithelial cells. Here, we hypothesized that decreased urinary excretion of 3-indoxyl sulfate (3-IS), the major conjugate of indole found in...

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Identifiers

PMID: 26209659
DOI: 10.1182/blood-2015-04-638858

Genes

NOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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