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Article

Monomerization alters the dynamics of the lid region in Campylobacter jejuni CstII: an MD simulation study.

Journal of biomolecular structure & dynamics - 1 Jan 2016

Prabhakar Pradeep Kumar, Srivastava Alka, Rao K Krishnamurthy, Balaji Petety V

Abstract excerpt

CstII, a bifunctional (α2,3/8) sialyltransferase from Campylobacter jejuni, is a homotetramer. It has been reported that mutation of the interface residues Phe121 (F121D) or Tyr125 (Y125Q) leads to monomerization and partial loss of enzyme activity, without any change in the secondary or tertiary structures. MD simulations of both tetramer and monomer, with and without bound donor substrate, were performed for...

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Identifiers

PMID: 26208676
DOI: 10.1080/07391102.2015.1054430

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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