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Article

The Cys78-Asn88 loop region of the Campylobacter jejuni CstII is essential for α2,3-sialyltransferase activity: analysis of the His85 mutants.

Journal of biochemistry - 1 Oct 2014

Prabhakar Pradeep Kumar, Rao K Krishnamurthy, Balaji Petety V

Abstract excerpt

CstII is a bifunctional sialyltransferase from Campylobacter jejuni that is active as a tetramer. CstIIs from different strains show substantial differences in enzyme activities (mono- versus bi-functional) and kinetic parameters. Crystal structures of CstII show that His85, conserved in CstIIs from different strains is part of an 11-residue loop that abuts the extended acceptor-binding site and is also part of...

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PMID: 24817703
DOI: 10.1093/jb/mvu033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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